This one has me baffled at the moment - I've just rebuilt my laptop with Vista Home Premium, SP2 and all updates. After what looks like a normal bootup, applications will not start. The mouse moves normally over icons, but will not show the info popup in the Quick Launch or the System Tray. Clicking these icons is ineffective. I can open other items on the desktop - eg Computer - but this will not explore further or close.
The only workaround I have at the moment is to start Task Manager, and this is the baffler. As soon as TM is opened everything behaves normally and continues to do so until next bootup. Closing TM immediately is also ok. I've uninstalled Avast AV and installed MSE instead, both seem to work but the problem remains (it was also there before I finished the updates) I've put Task Manager in Startup, but this doesn't work. Only running TM manually after startup seems to have an effect.
Any ideas??